Product Description
1-Ethyl-2-pyrrolidone features prominent transdermal absorption enhancing properties. Its interaction mechanism with multilamellar liposomes present in stratum corneum lipids has been fully investigated in relevant studies.
N-Ethyl-2-pyrrolidone (NEP) serves as a commonly used industrial solvent. With a moderately low boiling point, it is well-suited for applications under low-light and constant-pressure environmental conditions. Additionally, it acts as a key intermediate for the synthesis of polycarboxylic acids, and its performance is closely correlated with viscosity characteristics and hydrogen-bonding interactions.
Properties
| Melting point | 87.5-88.5 °C |
| Boiling point | 97 °C/20 mmHg (lit.) |
| density | 0.992 g/mL at 25 °C (lit.) |
| vapor pressure | 18Pa at 20℃ |
| refractive index | n20/D 1.465(lit.) |
| Fp | 169 °F |
| storage temp. | Sealed in dry,Room Temperature |
| pka | -0.41±0.20(Predicted) |
| form | Liquid |
| color | Clear |
| PH | 8-9 (100g/l, H2O, 20℃) |
| explosive limit | 1.3-7.7%(V) |
| Water Solubility | 1000g/L at 23℃ |
| BRN | 107971 |
| InChIKey | ZFPGARUNNKGOBB-UHFFFAOYSA-N |
| LogP | -0.2 at 20℃ |
| CAS DataBase Reference | 2687-91-4(CAS DataBase Reference) |
| NIST Chemistry Reference | 1-Ethyl-2-pyrrolidinone(2687-91-4) |
| EPA Substance Registry System | 2-Pyrrolidinone, 1-ethyl- (2687-91-4) |
Safety Information
| Hazard Codes | Xn,T |
| Risk Statements | 22-36-62-41-61 |
| Safety Statements | 26-36-45-36/37/39-53 |
| WGK Germany | 1 |
| RTECS | UY5769250 |
| TSCA | Yes |
| HS Code | 29337900 |
Product Application
NEP is a colorless, clear liquid acting as a low-volatility aprotic solvent. It exhibits strong solvency, low vapor pressure and a low dielectric constant.
Safety data shows N-Ethyl-2-pyrrolidone is categorized as a reproductive toxicant and may pose health risks under occupational exposure. Identified hazards cover acute solvent syndrome, potential hepatotoxicity, and reproductive toxicity, which may trigger developmental effects as well as adverse impacts on male and female reproductive functions.
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