Product Description
Dapsone is a sulfone-class antibacterial agent with strong activity against Mycobacterium leprae. Its formulations have been widely used in the treatment of leprosy and are recognized as a first-line therapy. Dapsone works by inhibiting bacterial dihydrofolate synthase (DHPs), thereby blocking folic acid synthesis and disrupting bacterial protein production.
In addition to its antibacterial effects, dapsone also exhibits significant anti-inflammatory activity. It effectively scavenges toxic oxygen free radicals generated after neutrophil stimulation, and inhibits neutrophil aggregation and activation, thereby reducing the release of inflammatory mediators and limiting tissue damage.
Clinical studies have shown that an oral dose of 100 mg dapsone can achieve blood concentrations 500–600 times higher than the minimum inhibitory concentration required to inhibit Mycobacterium leprae. In recent years, dapsone has also been found to be effective in other infectious diseases, inflammatory skin disorders, autoimmune bullous diseases, urticaria, and more, demonstrating a broad range of therapeutic applications.
Properties
| Melting point | 175-177 °C(lit.) |
| Boiling point | 511.7±35.0 °C(Predicted) |
| density | 1.2701 (rough estimate) |
| vapor pressure | 0.004Pa at 25℃ |
| refractive index | 1.5950 (estimate) |
| storage temp. | 2-8°C |
| solubility | 0.38g/l |
| form | Crystalline Powder |
| pka | pKb 13.0(at 25℃) |
| color | White to beige |
| PH | 5.5-7.5 (H2O, 20℃)(saturated aqueous solution) |
| Water Solubility | <0.1 g/100 mL at 20 ºC |
| Merck | 142822 |
| BRN | 788055 |
| BCS Class | 4,2 |
| Stability: | Stable. Combustible. Incompatible with strong oxidizing agents. |
| InChIKey | MQJKPEGWNLWLTK-UHFFFAOYSA-N |
| LogP | 0.97 at 25℃ |
| CAS DataBase Reference | 80-08-0(CAS DataBase Reference) |
| NIST Chemistry Reference | Dapsone(80-08-0) |
| IARC | 3 (Vol. 24, Sup 7) 1987 |
| EPA Substance Registry System | Dapsone (80-08-0) |
Safety Information
| Hazard Codes | Xn |
| Risk Statements | 22 |
| Safety Statements | 22 |
| RIDADR | 3249 |
| WGK Germany | 1 |
| RTECS | BY8925000 |
| TSCA | Yes |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 29051620 |
| HS Code | 29309070 |
| Hazardous Substances Data | 80-08-0(Hazardous Substances Data) |
| Toxicity | LD50 orally in Rabbit: 1000 mg/kg LD50 dermal Rabbit > 4000 mg/kg |
Product Application
4,4'-Diaminodiphenyl sulfone is an important aromatic sulfone compound produced through high-temperature and high-pressure amination processes. It is primarily used in the synthesis of polysulfoneamide resins and other polymeric materials, as well as in the production of various acidic azo dyes and disperse dyes.
In addition, it can serve as an epoxy resin curing agent and is used in electrical insulation materials and textile equipment applications. It also functions as a catalyst in certain chemical processes. In the pharmaceutical field, it is applied in the treatment of leprosy, herpetiform dermatitis, AIDS, and other diseases.
Factory Tour
Package And Shipping
Company Profile
Shandong Rongsheng Chemical Co., Ltd. is situated within a well‑developed chemical manufacturing belt in Shandong Province. As a comprehensive chemical enterprise covering manufacturing, technical research, domestic sales and global export businesses, we devote ourselves to supplying basic chemical feedstocks and multi‑purpose fine‑chemical additives. Our product offering serves numerous downstream industries, including rubber‑plastic processing, coating and ink formulation, water‑treatment projects and a wide range of industrial production activities.
Our self‑owned standardized manufacturing site enables full‑range quality management throughout production workflows to deliver genuine factory‑direct supplies. By skipping intermediate distribution channels, we deliver flexible procurement options for overseas purchasers, such as large‑volume bulk supply, custom formula research, individualized packaging solutions and small‑lot sample provision. Our adjustable production capacity can accommodate diverse client requirements to secure stable and punctual shipments.
Our proficient foreign‑trade team possesses solid practical experience dealing with global chemical markets. Thoroughly familiar with import specifications and cross‑border logistics rules across different nations, we provide overseas partners with complete one‑stop export services. Our service scope covers inquiry response, sample delivery, tailored solution development, customs clearance, cargo arrangement and sustained after‑sales support.
We stick to our core business value: quality‑first operation and mutually beneficial cooperation built on credibility. Supported by stable product performance, flexible service solutions and efficient, regulation‑compliant shipping capacity, we deliver cost‑effective and dependable integrated chemical supply‑chain solutions for worldwide buyers. We look forward to building long‑term trust‑based partnerships and becoming your preferred supplier within global fine‑chemical trade.
