Product Description
Diazolidinyl Urea (CAS# 78491-02-8) is a synthetic, highly water-soluble compound that appears as a white, odorless powder. It is widely used as a broad-spectrum antimicrobial preservative in cosmetics and personal care formulations. Acting as a formaldehyde-releasing agent, it helps inhibit microbial growth, typically at usage levels of 0.03% to 0.3%.
Properties
| Boiling point | 421.04°C (rough estimate) |
| density | 1.4734 (rough estimate) |
| vapor pressure | 0Pa at 20℃ |
| refractive index | 1.6590 (estimate) |
| storage temp. | 2-8°C |
| solubility | Water (Slightly) |
| form | Solid |
| pka | 11.22±0.46(Predicted) |
| color | White to Off-White |
| Water Solubility | 1000g/L at 20℃ |
| Merck | 143000 |
| Stability: | Stable. Incompatible with strong oxidizing agents. |
| InChIKey | SOROIESOUPGGFO-UHFFFAOYSA-N |
| LogP | 0.9 at 20℃ |
| CAS DataBase Reference | 78491-02-8(CAS DataBase Reference) |
| EPA Substance Registry System | Diazolidinylurea (78491-02-8) |
| Hazard Codes | Xi |
| Risk Statements | 43 |
| Safety Statements | 36/37 |
| WGK Germany | 2 |
| RTECS | YS2717000 |
| HS Code | 29339900 |
| Toxicity | LD50 orally in rats: 2.57 g/kg; dermally in rabbits: >2.0 g/kg (Berke, Rosen) |
Product Application
Diazolidinyl urea is suitable for use in both leave-on and rinse-off cosmetic products, including creams, lotions, shampoos, conditioners, liquid cosmetics, and eye makeup. It has been approved for use in both the United States and the European Union. The typical usage level is 0.1%–0.3%, and it is recommended to add it at temperatures below 50°C. It can also be combined with parabens and IPBC to improve its overall antimicrobial performance.
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